Recent research from the University of Nevada, Reno School of Medicine, indicates a substantial increase in overdose deaths among individuals aged 65 and older since 2015. This trend is primarily attributed to the presence of fentanyl combined with stimulants.

Story Highlights:

• Overdose deaths in seniors have risen by 9,000% since 2015, largely due to fentanyl and stimulants.
• The increase affects older adults at rates similar to younger populations, marking a “fourth wave” of the opioid crisis.
• Doctors suggest that chronic illness, multiple medication use (polypharmacy), and social isolation contribute to seniors’ vulnerability.
• Researchers recommend immediate, senior-focused prevention strategies.

Detailed Report:

Researchers from the University of Nevada, Reno School of Medicine, in collaboration with the American Society of Anesthesiologists and the CDC, have documented a 9,000% increase in overdose deaths among Americans aged 65 and older since 2015. This rise is linked to the combination of fentanyl and stimulants such as cocaine and methamphetamine. This development suggests that the opioid crisis, previously more associated with younger adults, now affects older populations at comparable rates. This surge is identified as the “fourth wave” of the opioid epidemic and highlights specific vulnerabilities in seniors, including chronic illnesses, the use of multiple medications, and age-related changes in drug metabolism.

Deadly drug mix drives staggering rise in overdose deaths among seniors:
America’s seniors aren't immune to the ongoing opioid epidemic.

Among adults 65 and older, overdose deaths from fentanyl mixed with stimulants — like cocaine and methamphetamines … https://t.co/ldZrgl5WPm

— Elwin Sidney (@ElwinSidney) October 17, 2025

Seniors frequently manage multiple chronic conditions and may be prescribed various medications, a practice known as polypharmacy. This, combined with slower drug metabolism due to aging, can increase the risk of accidental overdose. The illicit drug market, which includes fentanyl-laced substances, presents an additional risk, as many seniors may be unaware of the potency or presence of these drugs. Social isolation and untreated pain are also noted as factors that can exacerbate the danger.

The origins of this epidemic are connected to policy changes over several decades. The initial wave of the opioid crisis, driven by overprescription in the 1990s, transitioned to heroin abuse as prescription drugs became less accessible. By 2013, illicit fentanyl became more prevalent, and by 2015, fentanyl began to be mixed with stimulants. The consequences have been particularly pronounced for seniors, a group that has often been less emphasized in prevention and research efforts.

Data from the Centers for Disease Control and Prevention (CDC) indicate that while overdose deaths have decreased among younger Americans, they continue to rise among those aged 55 and older. This shift in trends suggests that older adults are increasingly affected, challenging the perception that opioid overdoses are primarily a problem for younger individuals.

Researchers from the University of Nevada, Reno School of Medicine, in collaboration with the American Society of Anesthesiologists and the CDC, have brought attention to this issue. Gab Pasia, lead author of a study presented at the 2025 ANESTHESIOLOGY annual meeting, stated that “older adults are also impacted by fentanyl-related deaths, and stimulant involvement has become much more common in this group.” Doctors emphasize that the unique vulnerabilities of seniors—chronic illness, polypharmacy, and slower metabolism—require immediate and tailored responses. The study highlights the need for more targeted research and prevention strategies, noting that the specific behavioral or systemic drivers are not yet fully understood.

The effects of this trend are observed across society. Families are affected by the loss of individuals, and caregivers face increased responsibilities. Healthcare providers are adapting to incorporate overdose prevention and education for seniors. Economic costs are increasing due to rising emergency response and healthcare expenditures. Politically, there is increasing pressure on policymakers to address gaps in addiction treatment and prevention for older adults.

This situation highlights the impact of various policies. As discussions around border security and law enforcement priorities continue, it is noted that vigilance is required to ensure that lessons are applied and that the safety of vulnerable citizens is addressed.

Watch the report: Older Adults and Opioid Overdose Death

Sources:

Drug OD Deaths Rising for Ages 65 Plus: What We Know (WebMD)
Drug Overdose Data (CDC)
Deadly drug mix drives staggering rise in overdose deaths among seniors (Fox News)
Deadly drug mix drives staggering rise in overdose deaths among seniors (Science Daily)
Adults 65 Years and Older Are Not Immune to Opioid Crisis (Medical Xpress)